In the framework of the systematic investigation of the environment of
the district of Teplice (Northern Bohemia), one of the most polluted
regions in Europe, an attempt was made to estimate health risks to the
inhabitants posed by the most common air contaminants (SO2, NOx, part
iculate matter). A meta-analysis of data published in recent papers de
aling with health effects was performed. At first we weighed the numbe
r of positive and negative findings focusing on the following health i
ndicators: prevalence of symptoms (coughing, wheezing), decreased resp
iratory function, prevalence of respiratory illness, and acute mortali
ty. Only those categories in which the positive findings prevailed wer
e taken into consideration and median values for LOAELs were calculate
d from the data referring to positive dose-response relationships. The
exposure assessment was based upon a series of data on daily concentr
ations of the air contaminants in Teplice since 1975. Due to the somat
ic and respiration parameters, as well as to their habits, children be
tween the ages of 8 and 10 appeared the most heavily exposed of all ag
e groups. Tt was concluded that in real concentrations the risk is pos
ed mainly from sulphur dioxide and, above all, from particulate matter
. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.