Histologic evaluations of neck dissection specimens from carcinomas of
the head and neck provide information required for disease staging, p
lanning further treatment, and prognosis. Histologic evaluation perfor
med adequately and accurately can and continues to provide a more accu
rate, meaningful, and promising means of formulating and predicting pr
ognosis including risk of metastases. A multi-institutional study usin
g comprehensive standardized histologic evaluation of histopathologic
variables of primary tumor and cervical lymph nodes among homogenous p
atient groups receiving similar therapy is important. Histopathologic
parameters remain an important adjunct parameter to clinical evaluatio
n in guiding, planning treatment, and predicting prognosis for patient
s with head and neck cancers.