THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A NOVEL SERIES OF DIAZEPINE MMP INHIBITORS

Authors
LEVIN JI DIJOSEPH JF KILLAR LM SUNG A WALTER T SHARR MA ROTH CE SKOTNICKI JS ALBRIGHT JD
Citation
Ji. Levin et al., THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF A NOVEL SERIES OF DIAZEPINE MMP INHIBITORS, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2657-2662
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
19
Year of publication
1998
Pages
2657 - 2662
Database
ISI
SICI code
0960-894X(1998)8:19<2657:TSABOA>2.0.ZU;2-H
Abstract
A novel series of diazepine-based hydroxamic acid inhibitors of MMP-1, MMP-9, and MMP-13 were prepared and evaluated both in vitro and in vi vo. (C) 1998 Elsevier Science Ltd. All rights reserved.