PYRROLES AND OTHER HETEROCYCLES AS INHIBITORS OF P38 KINASE

Authors
DELASZLO SE VISCO D AGARWAL L CHANG L CHIN J CROFT G FORSYTH A FLETCHER D FRANTZ B HACKER C HANLON W HARPER C KOSTURA M LI B LUELL S MACCOSS M MANTLO N ONEILL EA OREVILLO C PANG M PARSONS J ROLANDO A SAHLY Y SIDLER K WIDMER WR OKEEFE SJ
Citation
Se. Delaszlo et al., PYRROLES AND OTHER HETEROCYCLES AS INHIBITORS OF P38 KINASE, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2689-2694
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
19
Year of publication
1998
Pages
2689 - 2694
Database
ISI
SICI code
0960-894X(1998)8:19<2689:PAOHAI>2.0.ZU;2-M
Abstract
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl -2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. -fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrole (L-167307) reduces secondary paw swelling in the rat adjuvant arthritis model: ID 50 = 7.4 mg/kg/b.i.d. (C) 1998 Elsevier Science Ltd. All rights reserv ed.