CONFORMATIONALLY CONSTRAINED INHIBITORS OF CASPASE-1 (INTERLEUKIN-1-BETA CONVERTING-ENZYME) AND OF THE HUMAN CED-3 HOMOLOG CASPASE-3 (CPP32, APOPAIN)

Authors
KARANEWSKY DS BAI X LINTON SD KREBS JF WU J PHAM B TOMASELLI KJ
Citation
Ds. Karanewsky et al., CONFORMATIONALLY CONSTRAINED INHIBITORS OF CASPASE-1 (INTERLEUKIN-1-BETA CONVERTING-ENZYME) AND OF THE HUMAN CED-3 HOMOLOG CASPASE-3 (CPP32, APOPAIN), Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2757-2762
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
19
Year of publication
1998
Pages
2757 - 2762
Database
ISI
SICI code
0960-894X(1998)8:19<2757:CCIOC(>2.0.ZU;2-5
Abstract
A systematic study of interleukin-lp converting enzyme (ICE, caspase-1 ) and caspase-3 (CPP32, apopain) inhibitors incorporating a PGammaP3 c onformationally constrained dipeptide mimetic is reported. Depending o n the nature of the P-4 substituent, highly selective inhibitors of bo th Csp-l or Csp-3 were obtained. (C) 1998 Elsevier Science Ltd. All ri ghts reserved.