2-PYRIDINYL-3-(4-METHYLSULFONYL)PHENYLPYRIDINES - SELECTIVE AND ORALLY-ACTIVE CYCLOOXYGENASE-2 INHIBITORS

Authors
FRIESEN RW BRIDEAU C CHAN CC CHARLESON S DESCHENES D DUBE D ETHIER D FORTIN R GAUTHIER JY GIRARD Y GORDON R GREIG GM RIENDEAU D SAVOIE C WANG ZY WONG E VISCO D XU LJ YOUNG RN
Citation
Rw. Friesen et al., 2-PYRIDINYL-3-(4-METHYLSULFONYL)PHENYLPYRIDINES - SELECTIVE AND ORALLY-ACTIVE CYCLOOXYGENASE-2 INHIBITORS, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2777-2782
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
19
Year of publication
1998
Pages
2777 - 2782
Database
ISI
SICI code
0960-894X(1998)8:19<2777:2-SAO>2.0.ZU;2-1
Abstract
A series of novel 2-pyridinyl-3-(4-methylsulfonyl)phenylpyridines has been synthesized and evaluated with respect to their ability to inhibi t the isozymes of cyclooxygenase, COX-I, and COX-2. Optimum COX-2 acti vity is observed by introduction of a substituent at C5 of the central pyridine. ylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine 33 was i dentified as the optimum compound in this series. (C) 1998 Published b y Elsevier Science Ltd. All rights reserved.