SIALYL-LEWIS-X POLYSACCHARIDE CONJUGATES - TARGETING INFLAMMATORY LESIONS

Authors
SAKAGAMI M HORIE K NAKAMOTO K KAWAGUCHI T HAMANA H
Citation
M. Sakagami et al., SIALYL-LEWIS-X POLYSACCHARIDE CONJUGATES - TARGETING INFLAMMATORY LESIONS, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2783-2786
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
19
Year of publication
1998
Pages
2783 - 2786
Database
ISI
SICI code
0960-894X(1998)8:19<2783:SPC-TI>2.0.ZU;2-Q
Abstract
A novel system for active targeting of inflammatory lesions has been e stablished. A SLe(X)-CMPul conjugate (2) showed accumulation that was 2.5-fold higher in inflammatory lesions in vivo than a SLN-CMPul conju gate (4) and 300-fold higher than monovalent SLe(X) (6). (C) 1998 Else vier Science Ltd. All rights reserved.