SYNTHESIS AND IMMUNOSUPPRESSANT ACTIVITY OF PYRAZOLE CARBOXAMIDES

Authors
WANG AX XIE QH LANE B MOLLISON KW HSIEH GC MARSH K SHEETS MP LULY JR COGHLAN MJ
Citation
Ax. Wang et al., SYNTHESIS AND IMMUNOSUPPRESSANT ACTIVITY OF PYRAZOLE CARBOXAMIDES, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2787-2792
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
19
Year of publication
1998
Pages
2787 - 2792
Database
ISI
SICI code
0960-894X(1998)8:19<2787:SAIAOP>2.0.ZU;2-C
Abstract
A series of novel pyrazole carboxamides is disclosed that demonstrate strong immunosuppressant activity in rodent and human mixed leukocyte response (MLR) assays (IC50 < 1 mu M). The synthesis, biological activ ity, mode of action, and pharmacokinetic properties of this new lead s eries are discussed. (C) 1998 Elsevier Science Ltd. All rights reserve d.