DESIGN AND SYNTHESIS OF DIPEPTIDYL ALPHA',BETA'-EPOXY KETONES, POTENTIRREVERSIBLE INHIBITORS OF THE CYSTEINE PROTEASE CRUZAIN

Authors
ROUSH WR GONZALEZ FV MCKERROW JH HANSELL E
Citation
Wr. Roush et al., DESIGN AND SYNTHESIS OF DIPEPTIDYL ALPHA',BETA'-EPOXY KETONES, POTENTIRREVERSIBLE INHIBITORS OF THE CYSTEINE PROTEASE CRUZAIN, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2809-2812
Citations number
36
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
19
Year of publication
1998
Pages
2809 - 2812
Database
ISI
SICI code
0960-894X(1998)8:19<2809:DASODA>2.0.ZU;2-F
Abstract
The dipeptidyl epoxy ketone 4 is a potent, irreversible inhibitor of c ruzain, a cysteine protease isolated from Trypanosoma cruzi, with an a pparent second order inhibition rate constant of 330,000 sec(-1)M(-1). (C) 1998 Elsevier Science Ltd. All rights reserved.