We report a 57-years-old male with a 11-years history of Crohn's disea
se who developed small bowel adenocarcinoma. The patient was admitted
with intestinal partial obstruction and he under went a laparotomy bec
ause an abscess in right lower quadrant was suspected. He was successf
ully treated with resection and adjuvant chemotherapy, without evidenc
e of recurrence after a 2-year follow-up. A review of the literature r
eveals that about 100 cases have been reported. We describe the distin
guishing features of small bowel adenocarcinoma arising in Crohn's dis
ease and we emphasize the difficulty in making an early diagnosis.