AZOLIDENE CARBENES DERIVED FROM BIOLOGICALLY RELEVANT MOLECULES - SYNTHESIS AND CHARACTERIZATION OF IRIDIUM COMPLEXES OF IMIDAZOLIDENE LIGANDS BASED UPON THE ANTIFUNGAL DRUGS ECONAZOLE AND MICONAZOLE

Authors
DAVIS JH LAKE CM BERNARD MA
Citation
Jh. Davis et al., AZOLIDENE CARBENES DERIVED FROM BIOLOGICALLY RELEVANT MOLECULES - SYNTHESIS AND CHARACTERIZATION OF IRIDIUM COMPLEXES OF IMIDAZOLIDENE LIGANDS BASED UPON THE ANTIFUNGAL DRUGS ECONAZOLE AND MICONAZOLE, Inorganic chemistry, 37(21), 1998, pp. 5412
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Inorganic chemistry → ACNP
ISSN journal
00201669
Volume
37
Issue
21
Year of publication
1998
Database
ISI
SICI code
0020-1669(1998)37:21<5412:ACDFBR>2.0.ZU;2-J
Abstract
The azole-based antifungal drugs econazole and miconazole are readily converted into imidazolidene carbenes, which are trapped by coordinati on to iridium(I). The resulting complexes are the first antifungal dru g-metal conjugates incorporating an M-C sigma bond. This demonstration of the capacity of azole-containing bioactive molecules to form carbe ne ligands may open the door to the investigation of complexes derived from such species for a variety of biological and medicinal purposes.