PHYSIOLOGICAL ACTIVATION OF PEROXIDATION BY NEGATIVE AIR IONS

The effect of negative air ions (NAI) was investigated on physiologica l processes of peroxidative oxidation in mitochondria preserving their native structure organization in associations in rat liver homogenate . Tchijevsky lustre generating superoxide was served as a source of NA I. The investigated objects were put into solutions pretreated with NA I flow. An increase of peroxide induced Ca2+ release from mitochondria loaded with the cation was found. Under prolonged action of NAI flow on homogenates kept: in ice followed by incubation in media pretreated with NAI an elevation of products of peroxide lipid oxidation (POL) w as found in case of their low initial level and decrease of POL produc ts in case of their high initial level. The range of changes is consid erably less than under pathogeneous rise of POL. The discovered mild a ctivation of peroxidative oxidation within physiological range of POL concentrations is considered as a primary physico-chemical mechanism o f beneficial biological action of NAI.