WAY-100635 REVERSES 8-OH-DPAT-INDUCED PERFORMANCE IMPAIRMENT IN THE RADIAL MAZE

Authors
HELSLEY S SIEGEL TL FIORELLA D RABIN RA WINTER JC
Citation
S. Helsley et al., WAY-100635 REVERSES 8-OH-DPAT-INDUCED PERFORMANCE IMPAIRMENT IN THE RADIAL MAZE, Progress in neuro-psychopharmacology & biological psychiatry, 22(7), 1998, pp. 1179-1184
Citations number
7
Categorie Soggetti
Neurosciences,"Clinical Neurology","Pharmacology & Pharmacy",Psychiatry
Journal title
Progress in neuro-psychopharmacology & biological psychiatry → ACNP
ISSN journal
02785846
Volume
22
Issue
7
Year of publication
1998
Pages
1179 - 1184
Database
ISI
SICI code
0278-5846(1998)22:7<1179:WR8PII>2.0.ZU;2-A
Abstract
1. The effects of the 5-HT1A receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT1A antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performa nce (% correct arm entries) and response rate (arms/min) compared with the saline condition. 3, These effects were completely blocked by WAY -100635 which by itself had no effect on efficiency or response Fate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze per formance.