SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 7-(3-SUBSTITUTED-3 OR ROMETHYL-1-PYRROLIDINYL)-8-METHOXYFLUOROQUINOLONES

Authors
FUKUI H SHIBATA T NAITO T NAKANO J MAEJIMA T SENDA H IWATANI W TATSUMI Y SUDA M ARIKA T
Citation
H. Fukui et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 7-(3-SUBSTITUTED-3 OR ROMETHYL-1-PYRROLIDINYL)-8-METHOXYFLUOROQUINOLONES, Bioorganic & medicinal chemistry letters, 8(20), 1998, pp. 2833-2838
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
20
Year of publication
1998
Pages
2833 - 2838
Database
ISI
SICI code
0960-894X(1998)8:20<2833:SAAAON>2.0.ZU;2-X
Abstract
The titled compounds were synthesized and evaluated for in vitro antib acterial activity. The (3R,4S)-3-aminomethyl-4-trifluoromethyl derivat ive (S-34109) was confirmed to be optimal because of its superior acti vity against quinolone and methicillin-resistant Staphyrococcus aureus and low side effect potential. (C) 1998 Elsevier Science Ltd. All rig hts reserved.