FUSED AMINOTETRALINS - NOVEL ANTAGONISTS WITH HIGH SELECTIVITY FOR THE DOPAMINE D-3 RECEPTOR

Authors
AVENELL KY BOYFIELD I COLDWELL MC HADLEY MS HEALY MAM JEFFREY PM JOHNSON CN NASH DJ RILEY GJ SCOTT EE SMITH SA STACEY R STEMP G THEWLIS KM
Citation
Ky. Avenell et al., FUSED AMINOTETRALINS - NOVEL ANTAGONISTS WITH HIGH SELECTIVITY FOR THE DOPAMINE D-3 RECEPTOR, Bioorganic & medicinal chemistry letters, 8(20), 1998, pp. 2859-2864
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
20
Year of publication
1998
Pages
2859 - 2864
Database
ISI
SICI code
0960-894X(1998)8:20<2859:FA-NAW>2.0.ZU;2-U
Abstract
Starting from a series of 2-aminotetralins 1, a novel series of phenyl benzoylamino)butyl]-octahydrobenzoquinolines and hexahydrobenzoindoles with high potency and selectivity for the dopamine Dg receptor has be en designed. The effect of ligand chirality on binding affinity has be en established. Selected derivatives (e.g. 2o, 2p) show high functiona l selectivity and enhanced in vivo properties compared to 1. (C) 1998 Elsevier Science Ltd. All rights reserved.