FIRST SYNTHESIS OF ALTERNATING SATE-PHOSPHOTRIESTER PHOSPHODIESTER PROOLIGONUCLEOTIDES ON SOLID SUPPORT/

Authors
TOSQUELLAS G BOLOGNA JC MORVAN F RAYNER B IMBACH JL
Citation
G. Tosquellas et al., FIRST SYNTHESIS OF ALTERNATING SATE-PHOSPHOTRIESTER PHOSPHODIESTER PROOLIGONUCLEOTIDES ON SOLID SUPPORT/, Bioorganic & medicinal chemistry letters, 8(20), 1998, pp. 2913-2918
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
8
Issue
20
Year of publication
1998
Pages
2913 - 2918
Database
ISI
SICI code
0960-894X(1998)8:20<2913:FSOASP>2.0.ZU;2-A
Abstract
Prooligonucleotides with alternating S-Acyl-ThioEthyl (SATE) phosphotr iester and phosphodiester linkages or a gap were synthesized by elimin ation of cyanoethyl group with non-nucleophilic base DBU. Their half-l ives in the presence of pig Liver Esterases (PLE) and in total cell ex tract were determined. (C) 1998 Elsevier Science Ltd. All rights reser ved.