BRAIN MECHANISMS OF SOCIAL ANXIETY DISORDER

Citation
Dj. Nutt et al., BRAIN MECHANISMS OF SOCIAL ANXIETY DISORDER, The Journal of clinical psychiatry, 59, 1998, pp. 4-11
Citations number
42
Categorie Soggetti
Psycology, Clinical",Psychiatry,Psychiatry
ISSN journal
01606689
Volume
59
Year of publication
1998
Supplement
17
Pages
4 - 11
Database
ISI
SICI code
0160-6689(1998)59:<4:BMOSAD>2.0.ZU;2-3
Abstract
The neurobiology of social anxiety disorder is poorly understood, alth ough preliminary research has suggested several possible biological ab normalities. Challenge studies have demonstrated that subjects with so cial anxiety disorder have a sensitivity to carbon dioxide, cholecysto kinin, and caffeine somewhere between that of panic disorder patients and normal controls. Serotonergic pathways may play a role in social a nxiety disorder, as shown by the clinical effectiveness of selective s erotonin reuptake inhibitors, plus fenfluramine and m-chlorophenylpipe razine challenge studies. Dopaminergic function and striatal dopamine uptake appear to be reduced in social anxiety disorder. There is also evidence for cardiovascular and adrenergic abnormalities. Recently, po sitron emission tomography has begun to identify brain regions that ap pear to be uniquely activated in this condition. These results offer t he promise of an understanding of the brain mechanisms of social anxie ty disorder, but much further research is needed to fully elucidate th e neurobiological cause(s) that exist.