CHARACTERIZATION OF A 34-KILODALTON PROTEIN OF MYCOBACTERIUM-LEPRAE THAT IS ISOLOGOUS TO THE IMMUNODOMINANT 34-KILODALTON ANTIGEN OF MYCOBACTERIUM-PARATUBERCULOSIS

Authors
SILBAQ FS CHO SN COLE ST BRENNAN PJ
Citation
Fs. Silbaq et al., CHARACTERIZATION OF A 34-KILODALTON PROTEIN OF MYCOBACTERIUM-LEPRAE THAT IS ISOLOGOUS TO THE IMMUNODOMINANT 34-KILODALTON ANTIGEN OF MYCOBACTERIUM-PARATUBERCULOSIS, Infection and immunity (Print), 66(11), 1998, pp. 5576-5579
Citations number
21
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity (Print) → ACNP
ISSN journal
00199567
Volume
66
Issue
11
Year of publication
1998
Pages
5576 - 5579
Database
ISI
SICI code
0019-9567(1998)66:11<5576:COA3PO>2.0.ZU;2-C
Abstract
During DNA sequence analysis of cosmid L373 from the Mycobacterium lep rae genome, an open reading frame of 1.4 kb encoding a protein with so me homology to the immunodominant 34-kDa protein of Mycobacterium para tuberculosis, but lacking significant serological activity, was detect ed. The DNA sequence predicted a signal peptide with a modified lipopr otein consensus sequence, but the protein proved to be devoid of lipid attachment.