EFFECTS OF GR203040, AN NK1 ANTAGONIST, ON RADIATION-INDUCED AND CISPLATIN-INDUCED TISSUE-DAMAGE IN THE FERRET

1. The effects of GR203040, a tachykinin neurokinin(1) receptor antago nist, on tissue damage induced by X-irradiation (Rad) or cisplatin (Ci sp) were investigated in ferrets. 2. GR203040 (0.3 mg/kg SC) reduced t he Rad-induced plasma protein extravasation (PPE) in the duodenum and kidney by 25% in each tissue. 3. GR203040 (3 mg/kg SC, 5-min pretreatm ent and every 8 hr for 48 hr after Cisp) reduced the Cisp-induced PPE in the duodenum, jejunum and lung by 59, 52 and 60%, respectively. 4. Histological examination showed that GR203040 also ameliorated the Rad and Cisp-induced tissue damage. (C) 1998 Elsevier Science Inc.