EFFECT OF YM435, A DOPAMINE DA(1) RECEPTOR AGONIST, IN A CANINE MODELOF ISCHEMIC ACUTE-RENAL-FAILURE

1. The effects of oxyphenyl)-1,2,3,4-tetrahydroisoquinoline-7,8-diol m onohydrochloride monohydrate (YM435), a dopamine DA1 receptor agonist, were evaluated in a canine model of ischemic acute renal failure (ARF ). 2. ARF was induced by clamping the left renal artery for 1 hr and s ubsequent reperfusion of the left kidney in anesthetized uninephrectom ized dogs. 3. After 1-hr complete renal artery occlusion, an intraveno us infusion of either YM435 (0.3 mu g/kg/min) or 0.9% saline (vehicle) was begun and continued for 1 hr. 4. In the vehicle group, renal isch emia markedly decreased glomerular filtration rate, urine flow and uri nary sodium excretion. The YM435 group was characterized by significan t recoveries in glomerular filtration rate, urine flow, and urinary so dium excretion as compared with the vehicle group. 5. These results in dicate that YM435 can facilitate recovery in glomerular filtration rat e, urine flow, and urinary sodium excretion in a canine model of ARF i nduced by ischemia. YM435 may be useful in the preservation of renal f unction in ischemia-induced ARF. (C) 1998 Elsevier Science Inc.