Scopulariopsis, a sail saprophyte, rarely produces disease and has not
been reported to cause invasive nasal destruction in a nonimmunocompr
omised host. We report the first case of Scopulariopsis in the otolary
ngology literature. Prompt surgical debridement is required and usuall
y adequate. Disagreement exists on the use of antifungals as an effect
ive treatment A case of invasive Scopulariopsis involving the nasal se
ptum of a 72-year-old man is detailed, and successful treatment consis
ted of local debridement without antifungal drugs. His diagnosis, clin
ical course, and outcome illustrates the expanding differential diagno
sis faced by the otolaryngologist in patients with nasal disease.