SYNTHESIS, SPECTRAL AND ANTIMICROBIAL PROPERTIES OF 5-CHLOROARYLIDENEAROMATIC DERIVATIVES OF IMIDAZOLINE-4-ONE

The synthesis of new chloro-benzylidene substituted derivatives of hyd antoin and their antimicrobial activity is reported. The structure-act ivity relationships showed that the antibacterial effect of investigat ed compounds depends on the distance of the phenyl ring from the amine residue and the kind of substitutes on the phenyl ring. In the invest igated group of derivatives, ylidene)-2-(4-fluorobenzylamine)-imidazol ine-4-one and ylidene)-2-(2-phenyl-ethylamine)-imidazoline-4-one showe d the best antibacterial activity against Moraxella catarrhalis.