1,2,5-OXADIAZOLE N-OXIDE DERIVATIVES AS HYPOXIA-SELECTIVE CYTOTOXINS - STRUCTURE-ACTIVITY-RELATIONSHIPS

Authors
MONGE A DECERAIN AL EZPELETA O CERECETTO H DIAS E DIMAIO R GONZALEZ M ONETTO S RISSO M SEOANE G ZINOLA F OLEAAZAR C
Citation
A. Monge et al., 1,2,5-OXADIAZOLE N-OXIDE DERIVATIVES AS HYPOXIA-SELECTIVE CYTOTOXINS - STRUCTURE-ACTIVITY-RELATIONSHIPS, Die Pharmazie, 53(10), 1998, pp. 698-702
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
53
Issue
10
Year of publication
1998
Pages
698 - 702
Database
ISI
SICI code
0031-7144(1998)53:10<698:1NDAHC>2.0.ZU;2-H
Abstract
Structure-activity, relationship studies on a series of 1,2,5-oxadiazo le N-oxide derivatives showing cytotoxic activity have been performed. The mechanism of action could be related with free radical production .