ALLELE POLYMORPHISM OF 2 TETRANUCLEOTIDE TANDEM REPEATS IN 2 CITY POPULATIONS OF RUSSIA

PCR analysis of the allele polymorphism of two tetranucleotide tandem repeats (STR) HUMvWFII and D6S366 among unrelated Russians living in M oscow and Tomsk (Siberia) revealed seven HUMvWFII alleles of 154-174 b p and eight D6S366 alleles of 142-170 bp. For both loci the experiment al genotype frequencies corresponded to the Hardy-Weinberg equilibrium in both population samples. No significant differences in allele freq uency distribution were found between the two city populations; compar isons were made with foreign samples. Family analysis (14 cases) demon strated Mendelian inheritance of the alleles of these loci. The polymo rphism information content of the loci was calculated. These STR could be used for personal identification and paternity tests.