TEMPORAL AND SPATIAL RELATIONSHIP OF PYLORUS TO ANTRODUODENAL MOTILITY IN FUNCTIONAL DYSPEPSIA

Objective To investigate the temporal and spatial relationship of pylo rus to antroduodenal motility in functional dyspepsia (FD). Methods El even healthy subjects (HS) and 14 patients with FD were studied. Antra l-pyloro-duodenal manometry was performed for 3 hours fasting and 2 ho urs after 80 Kcal of solid test meal. Results (1) The incidence of pha se III was 7/11 in HS and 3/14 in FD in antrum (P < 0.05), 8/11 and 4/ 14 in pylorus (P < 0.05), 10/11 and 6/14 in duodenum (P < 0.05), respe ctively. (2) The percentage of antropyloroduodenal coordinations durin g phase II of MMC was 58.5% in HS and 18.5% in FD (P < 0.001). (3) The pyloroduodenal coordination was 78.2% and 38.9% (P < 0.01) at 60 minu tes after meal and 77.1% and 54.0% (P < 0.01) at 120 minutes postprand ially in HS and in FD. (4) The percentage of isolated pyloric pressure waves (IPPWs) was 4.8%, 29.7% (P < 0.001) at 60 minutes, and 9.3%, 25 .1% (P < 0.01) at 120 minutes in HS and FD. Conclusions There were abn ormalities of gastro-pyloro-duodenal motility in both interdigestive a nd digestive stages; the higher incidence of IPPWs and disordered temp oral and spatial relationship of pylorus to antroduodenal motility may result in a delayed gastric emptying in FD. The possible mechanism ma y be involved in abnormal neural control.