ANTIMICROBIAL ACTIVITY OF THE SEMISYNTHETIC COMPOUND, HEXAHYDROCOLUPULONE

Citation
Te. Stephan et al., ANTIMICROBIAL ACTIVITY OF THE SEMISYNTHETIC COMPOUND, HEXAHYDROCOLUPULONE, Journal of antimicrobial chemotherapy, 42(4), 1998, pp. 519-522
Citations number
10
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy","Infectious Diseases
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
42
Issue
4
Year of publication
1998
Pages
519 - 522
Database
ISI
SICI code
Abstract
In this study we demonstrate that hexahydrocolupulone (HHC) more effec tively inhibits the growth in vitro of Gram-positive organisms than My cobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Ent erococcus faecium, methicillin-resistant Staphylococcus aureus, and co agulase-negative staphylococci were inhibited by HHC at concentrations less than or equal to 4.06 mg/L. Growth inhibition profiles varied ac cording to the microorganism evaluated (static for S. aureus and bacte ricidal for Bacillus subtilis).