ANTIMICROBIAL ACTIVITY OF THE SEMISYNTHETIC COMPOUND, HEXAHYDROCOLUPULONE

In this study we demonstrate that hexahydrocolupulone (HHC) more effec tively inhibits the growth in vitro of Gram-positive organisms than My cobacterium tuberculosis or Escherichia coli. Vancomycin-resistant Ent erococcus faecium, methicillin-resistant Staphylococcus aureus, and co agulase-negative staphylococci were inhibited by HHC at concentrations less than or equal to 4.06 mg/L. Growth inhibition profiles varied ac cording to the microorganism evaluated (static for S. aureus and bacte ricidal for Bacillus subtilis).