COMPARATIVE ACTIVITY OF TROVAFLOXACIN AND BAY-12-8039 AGAINST 452 CLINICAL ISOLATES OF STREPTOCOCCUS-PNEUMONIAE

The principal aim of this study was to evaluate the in-vitro activity of new quinolones against clinical strains of Streptococcus pneumoniae . Four hundred and fifty-two single clinical isolates (of which 362 we re susceptible to penicillin, 54 intermediate and 36 highly resistant) were tested against penicillin, cefuroxime, ciprofloxacin, levofloxac in, trovafloxacin and Bay 12-8039. Of the tested S. pneumoniae strains , 97.1% had MICs of trovafloxacin of less than or equal to 0.25 mg/L, and 96.7% had MICs of Bay 12-8039 of less than or equal to 0.25 mg/L ( difference not statistically significant); 81.9% of strains had MICs o f cefuroxime of less than or equal to 0.25 mg/L (P less than or equal to 0.001 against both quinolones). Only 4% and 0.7% of the strains had MICs of levofloxacin and ciprofloxacin respectively of less than or e qual to 0.25 mg/L. Compared with older quinolones, trovafloxacin and B ay 12-8039 have good in-vitro activity against S. pneumoniae.