COMPARISON OF THE IN-VITRO ACTIVITY OF VORICONAZOLE (UK-109,496), ITRACONAZOLE AND AMPHOTERICIN-B AGAINST CLINICAL ISOLATES OF ASPERGILLUS-FUMIGATUS

Voriconazole was compared with amphotericin B and itraconazole by a mo dification of the NCCLS microdilution reference method for yeasts agai nst 62 clinical isolates of Aspergillus fumigatus. MICs of voriconazol e were slightly lower than those of amphotericin B and itraconazole. T he MIC of voriconazole at which 90% of isolates were inhibited was 1 m g/L and the MIC range was 0.25-2 mg/L. Voriconazole is a new antifunga l agent with potential for use in the treatment of A. fumigatus infect ions.