SCH56592 TREATMENT OF MURINE INVASIVE ASPERGILLOSIS

Authors
GRAYBILL JR BOCANEGRA R NAJVAR LK LUTHER MF LOEBENBERG D
Citation
Jr. Graybill et al., SCH56592 TREATMENT OF MURINE INVASIVE ASPERGILLOSIS, Journal of antimicrobial chemotherapy, 42(4), 1998, pp. 539-542
Citations number
25
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy","Infectious Diseases
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
42
Issue
4
Year of publication
1998
Pages
539 - 542
Database
ISI
SICI code
Abstract
Mice were immunosuppressed using corticosteroids and infected with con idia of Aspergillus fumigatus. Beginning 1 day after infection, mice w ere treated orally either with Noble agar or with SCH56592 suspended i n Noble agar, or intraperitoneally with amphotericin B. SCH56592 prolo nged survival and reduced lung tissue counts of A. fumigatus, while am photericin B had marginal benefit. SCH56592 merits further development for treatment of aspergillosis.