F. Humbert et al., DIFFUSION MEASUREMENTS USING RADIOFREQUENCY FIELD GRADIENT - ARTIFACTS, REMEDIES, PRACTICAL HINTS, Journal of magnetic resonance [1997], 134(2), 1998, pp. 245-254
Citations number
15
Categorie Soggetti
Physics, Atomic, Molecular & Chemical","Biochemical Research Methods
The two major advantages of experiments carried out with radiofrequenc
y (RF) field-gradient NMR are the instrumental simplicity and the inse
nsitivity to background static magnetic held gradients. These features
combined with large RF gradients, which became available only recentl
y, should make this technique especially attractive for molecular tran
slational diffusion studies. However, a critical evaluation of the met
hod shows that under some circumstances (small and/or heterogeneous sa
mples, weak diffusion coefficients, very short relaxation times) the q
uality of measurements may be affected by a number of artifacts. Their
origin has been investigated and several remedies have been considere
d; in particular, a new improved sequence is presented. The success of
various experimental tests demonstrates the efficiency of the propose
d solutions which thus open the way to much wider application fields.
(C) 1998 Academic Press.