DIFFUSION MEASUREMENTS USING RADIOFREQUENCY FIELD GRADIENT - ARTIFACTS, REMEDIES, PRACTICAL HINTS

Citation
F. Humbert et al., DIFFUSION MEASUREMENTS USING RADIOFREQUENCY FIELD GRADIENT - ARTIFACTS, REMEDIES, PRACTICAL HINTS, Journal of magnetic resonance [1997], 134(2), 1998, pp. 245-254
Citations number
15
Categorie Soggetti
Physics, Atomic, Molecular & Chemical","Biochemical Research Methods
Volume
134
Issue
2
Year of publication
1998
Pages
245 - 254
Database
ISI
SICI code
Abstract
The two major advantages of experiments carried out with radiofrequenc y (RF) field-gradient NMR are the instrumental simplicity and the inse nsitivity to background static magnetic held gradients. These features combined with large RF gradients, which became available only recentl y, should make this technique especially attractive for molecular tran slational diffusion studies. However, a critical evaluation of the met hod shows that under some circumstances (small and/or heterogeneous sa mples, weak diffusion coefficients, very short relaxation times) the q uality of measurements may be affected by a number of artifacts. Their origin has been investigated and several remedies have been considere d; in particular, a new improved sequence is presented. The success of various experimental tests demonstrates the efficiency of the propose d solutions which thus open the way to much wider application fields. (C) 1998 Academic Press.