Ij. Fuss et W. Strober, ANIMAL-MODELS OF INFLAMMATORY BOWEL-DISEASE - INSIGHTS INTO THE IMMUNOPATHOGENESIS OF CROHNS-DISEASE AND ULCERATIVE-COLITIS, Current opinion in gastroenterology, 14(6), 1998, pp. 476-482
Many diseases, including those characterized by inflammation of the ga
strointestinal tract (Crohn's disease and ulcerative colitis), are due
to an array of factors that act in concert to produce pathologic chan
ge. The immunologic factors that mediate the development of such mucos
al inflammation have been at the center of intense research. Recently,
a better understanding of the mechanisms involved in mucosal homeosta
sis and the occurrence of inflammatory bower disease (IBD) has been ac
hieved with the advent of animal models of mucosal inflammation. This
review discusses these models and the insights they provide into the p
athogenesis and treatment of IBD.