CRYSTAL-STRUCTURES OF HETEROCHIRAL PEPTIDES .2. TERT-BOC-VALYL-D-ALANYL-LEUCYL-ALANYL METHOXIDE

Authors
NAGARAJAN V PATTABHI V JOHNSON A BOBDE V DURANI S
Citation
V. Nagarajan et al., CRYSTAL-STRUCTURES OF HETEROCHIRAL PEPTIDES .2. TERT-BOC-VALYL-D-ALANYL-LEUCYL-ALANYL METHOXIDE, The journal of peptide research, 49(1), 1997, pp. 74-79
Citations number
27
Categorie Soggetti
Biology
Journal title
The journal of peptide research → ACNP
ISSN journal
1397002X
Volume
49
Issue
1
Year of publication
1997
Pages
74 - 79
Database
ISI
SICI code
1397-002X(1997)49:1<74:COHP.T>2.0.ZU;2-#
Abstract
Crystal structure of a heterochiral peptide, viz. Bac-Val(1)-D-Ala(2)- Leu(3)-Ala(4)-OMe with a D chiral residue in the second position of a sequence, has been determined [a = 40.44(1), b = 4.887(5), c = 15.381( 5) Angstrom, beta = 109.6(1)degrees, space group C2, Z = 4, R = 0.11]. The peptide is in a parallel beta-sheet structure terminated by a dis tinct local bend. The structure is stabilised by N-H ... O as well as C-alpha-N ... O hydrogen bonds,The contiguous C-alpha-H ... O hydrogen bond observed in this structure is an unique observation. (C) Munksga ard 1997.