DISTRIBUTION OF ALUMINUM SPECIES IN NORMAL URINE AS DETERMINED BY CHEMICAL NEUTRON-ACTIVATION ANALYSIS

A procedure developed for separating and quantifying non protein and p rotein fractions of aluminum species in urine was applied to four cons ecutive 24 hr collections of five healthy subjects. The total Al conte nt of urine was determined by a chemical neutron activation analysis t echnique reported elsewhere. Results from the analysis of all subjects indicate that the majority of aluminum is bound to protein (>88%) wit h minor fractions as citrate complexes. These data are comparable with other speciation experiments with blood plasma indicating 90% of the aluminum was bound to plasma proteins.