Haj. Gielkens et al., DOSE-DEPENDENT INHIBITION OF POSTPRANDIAL GALLBLADDER MOTILITY AND PLASMA-HORMONE SECRETION DURING ACUTE HYPERGLYCEMIA, Scandinavian journal of gastroenterology, 33(10), 1998, pp. 1074-1079
Background: Actual blood glucose concentrations influence gastrointest
inal function. We investigated whether in healthy subjects the inhibit
ory effect of acute hyperglycemia on gallbladder motility is dose-depe
ndent. Methods: Seven healthy volunteers were studied on four separate
occasions in random order during euglycemia and during hyperglycemic
clamping, at 4 mmol/l, 8 mmol/l, 12 mmol/l, and 16 mmol/l, respectivel
y. Gallbladder volumes (ultrasonography) and plasma hormone release we
re studied before and after ingestion of a meal. Results: Postprandial
gallbladder contraction was significantly (P < 0.05) and dose-depende
ntly inhibited during the hyperglycemic experiments at 8, 12, and 16 m
mol/l (56% +/- 8%, 49% +/- 8%, and 30% +/- 5%, respectively) compared
with euglycemia (68% +/- 6%). Postprandial cholecystokinin release was
significantly (P < 0.05) reduced compared with euglycemia only at a p
lasma glucose level of 16 mmol/l (116 +/- 28 Versus 159 +/- 13 pmol .
l(-1). 120 min). Plasma pancreatic polypeptide secretion, as an indire
ct measure of vagal-cholinergic tone, was significantly (P < 0.05) and
dose-dependently reduced during hyperglycemia at 8, 12, and 16 mmol/l
. Conclusion: In healthy subjects acute hyperglycemia significantly an
d dose-dependently inhibits postprandial gallbladder motility. Future
studies on gallbladder motility should take into account the influence
of plasma glucose, because already at postprandial glucose levels gal
lbladder motility is reduced.