TAMOXIFEN, A HUMAN CARCINOGEN OR THE SHARE OF COMMON RISK-FACTORS

Breast and endometrial cancers share common risk factors and therefore a slight excess risk of endometrial cancer is expected among breast c ancer patients. Yet, this does not explain the risk of endometrial can cer linked to tamoxifen use. When background risk is adequately contro lled, an effect of tamoxifen is still seen, increasing with duration o f use and further supported by experimental evidence of carcinogenicit y. (C) 1998 Elsevier Science Ltd. All rights reserved.