IATROGENIC RISKS OF ENDOMETRIAL CARCINOMA AFTER TREATMENT FOR BREAST-CANCER IN A LARGE FRENCH CASE-CONTROL STUDY

In a case-control study, including 135 cases of endometrial carcinoma diagnosed after breast cancer and 467 controls, the relative risks for endometrial carcinoma were higher for women treated with tamoxifen (4 .9; P=0.0001) and those who undergone pelvic radiotherapy (7; 8; P=0.0 001). After adjusting for confounding factors, a multivariate analysis has shown an increased risk of endometrial carcinoma for tamoxifen us ers, especially for treatment longer than 3 years and for pelvic radio therapy. Patients treated with tamoxifen had more advanced tumours and lower survival rates than those who had not received tamoxifen. (C) 1 998 Elsevier Science Ltd. All rights reserved.