Previous papers have already demonstrated the suitability, for single-
photon emission computed tomography (SPECT) tracers biodistribution st
udies on small animals, of a miniature gamma camera composed by a YAP:
Ce scintillating array 4 x 4 x 1 cm(3) coupled to a 3-in Hamamatsu cro
ssed-wire anode position sensitive photomultiplier (PSPMT). Some modif
ications have been applied to the imaging system readout in order to a
dapt its utilization for specific purposes (i,e., SPECT radiopharmaceu
tical testing) and to reduce construction costs so that a larger scale
production may be feasible. In particular, the system introduced here
is based on a resistive chain readout and an integrated acquisition e
lectronics. The intrinsic performance of this new version has been ana
lyzed and compared to the previous system, which had a single-wire rea
dout, Results showed that the basic characteristics of the imaging sys
tem remain substantially unchanged in this simplified version, while a
faster count rate is achieved. A test on a biological sample performe
d with the YAP camera both in single-mire and in resistive chain reado
ut modality is also presented, which shows the system high performance
in comparison to the Anger camera.