A NEWLY DEVELOPED ADENOVIRUS-MEDIATED TRANSFER OF A WILD-TYPE P53 GENE INCREASES SENSITIVITY TO CIS-DIAMMINEDICHLOROPLATINUM(II) IN P53-DELETED OVARIAN-CANCER CELLS

Authors
KANAMORI Y KIGAWA J MINAGAWA Y IRIE T OISHI T SHIMADA M TAKAHASHI M NAKAMURA T SATO K TERAKAWA N
Citation
Y. Kanamori et al., A NEWLY DEVELOPED ADENOVIRUS-MEDIATED TRANSFER OF A WILD-TYPE P53 GENE INCREASES SENSITIVITY TO CIS-DIAMMINEDICHLOROPLATINUM(II) IN P53-DELETED OVARIAN-CANCER CELLS, European journal of cancer, 34(11), 1998, pp. 1802-1806
Citations number
22
Categorie Soggetti
Oncology
Journal title
European journal of cancer → ACNP
ISSN journal
09598049
Volume
34
Issue
11
Year of publication
1998
Pages
1802 - 1806
Database
ISI
SICI code
0959-8049(1998)34:11<1802:ANDATO>2.0.ZU;2-F
Abstract
A new recombinant adenovirus carrying a wild-type p53 gene (AxCAp53) w as developed and the combination effect of p53 gene transfer and cis-d iamminedichloroplatinum (II) (CDDP) was examined in an ovarian cancer cell line, SK-OV-3, with deletion of the p53 gene. AxCAp53 showed a hi gh efficiency of gene transduction and increased sensitivity to CDDP i n the SK-OV-3 cells. It was found that the sensitivity of the cells to CDDP correlated with the amount of infectious units of virus per cell of AxCAp53 which correlated with p53 protein expression. The results suggest that the combination of CDDP and AxCAp53 may be a potential st rategy for the therapy of CDDP-resistant ovarian cancer. (C) 1998 Else vier Science Ltd. All rights reserved.