CLINICAL AND CARDIOPULMONARY EFFECTS OF ATROPINE-DIAZEPAM-KETAMINE WITH AND WITHOUT GUAIFENESIN IN CALVES SUFFERING FROM ACUTE-RENAL-FAILURE

Acute renal failure was produced by injecting uranyl nitrate @ 5 mg/kg body weight in 16 crossbred Jersey calves. Atropine sulphate @ 0.04 m g/kg im; diazepam @ 0.5 mg/kg iv - ketamine @ 5 mg/kg iv; or atropine @ 0.04 mg/kg im - diazepam @ 0.05 mg/kg iv - (guaifenesin 5% + thiopen tone 0.2%) @ 1.5 mg/kg - ketamine @ 5 mg/kg iv were given in 8 animals each respectively. A good anaesthesia with better muscle relaxation w as produced in animals given atropine-diazepam (guaifenesin + thiopent one) - ketamine. Significant (P<0.05) increase in heart rate, nonsigni ficant increase in respiratory rate, minute volume, mean arterial bloo d pressure and decrease in central venous pressure seen after their ad ministration were compensated in 30 to 90 min. ECG did not reveal any marked effect on heart. Both these anaesthetic drug combinations were tolerated well.