Cutaneous neosporosis manifested by pyogranulomatous ulcerative dermat
itis was diagnosed in an 11-year-old male Boxer. Histology revealed nu
merous intralesional protozoal tachysoites within macrophages and neut
rophils. Occasionally, tachysoites were observed within endothelial an
d epithelial cells. Infection with Neospora caninum was confirmed by a
vidin biotin complex immunohistochemistry using a Neospora-specific mo
noclonal antibody. Cutaneous neosporosis is rare and has only been pre
viously described in three cases. This report represents the first cas
e of canine neosporosis in Israel and the Middle East. (C) 1998 Elsevi
er Science B.V. All rights reserved.