VARICELLA-ZOSTER VIRUS ORF57, UNLIKE ITS PSEUDORABIES VIRUS UL3.5 HOMOLOG, IS DISPENSABLE FOR VIRAL REPLICATION IN CELL-CULTURE

Authors
COX E REDDY S IOFIN I COHEN JI
Citation
E. Cox et al., VARICELLA-ZOSTER VIRUS ORF57, UNLIKE ITS PSEUDORABIES VIRUS UL3.5 HOMOLOG, IS DISPENSABLE FOR VIRAL REPLICATION IN CELL-CULTURE, Virology (New York, N.Y. Print), 250(1), 1998, pp. 205-209
Citations number
13
Categorie Soggetti
Virology
Journal title
Virology (New York, N.Y. Print) → ACNP
ISSN journal
00426822
Volume
250
Issue
1
Year of publication
1998
Pages
205 - 209
Database
ISI
SICI code
0042-6822(1998)250:1<205:VVOUIP>2.0.ZU;2-J
Abstract
Varicella tester virus (VZV) encodes five genes that do not have homol ogs in herpes simplex virus. One of these genes, VN ORF57, is predicte d to encode a protein containing 71 amino acids. Antibody to ORF57 pro tein immunoprecipitated a 6-kDa protein in the cytosol of VZV-infected cells. Although the homolog of VZV ORF57 in pseudorabies virus, UL3.5 , is critical for viral egress and growth in cell culture, VN unable t o express ORF57 replicated to titers similar to those seen with parent al virus. Thus VZV ORF57 has a different role in Viral replication tha n its pseudorabies virus homolog.