ON THE GENETIC-ORIGIN OF COMPLEMENTARY PROTEIN-CODING

The relations of protein coding and hydropathy are investigated consid ering the principles of the molecular recognition theory and Grafstein 's hypothesis of the stereochemical origin of the genetic code. It is shown that the coding of RNA and DNA requires 14 distinct groups of co don-anticodon pairs, which define all possible complementary amino aci ds. The molecular recognition theory is redefined considering the codo n-anticodon relations of mRNAs, DNAs, tRNAs and Siemion's mutation rin g of the genetic code. A model of DNA, RNA and protein coding land dec oding) based on two fundamental properties of DNA/RNA, denoted as comp lementary and stationary principles, is presented. Stationary DNA/RNA coding defines the nucleotide relationship of the same (self) DNA/RNA strand and complementary coding defines nucleotide distribution relate d to other (non-self) strand. Combinations of 2 digits, denoting prima ry and secondary characteristics of each nucleotide, specify codon pos itions according to the group subdivision (discrimination) principle. The process of coding is related to the hypercube node codon represent ations and dynamics of their binary tree locations. The relations betw een binary tree locations and Canter set representations of different codon points are discussed in the context of quadratic mappings, Feige nbaum dynamics and signal analysis. Combinations of hypercube nodes an d different binary tree positions define the words, sentences and synt ax of DNA, RNA and protein language. Possible applications of this met hod may be related to network analysis and the design, gene, protein a nd drug modelling.