Sg. Kitchen et Ja. Zack, HIV TYPE-1 INFECTION IN LYMPHOID-TISSUE - NATURAL-HISTORY AND MODEL SYSTEMS, AIDS research and human retroviruses, 14, 1998, pp. 235-239
The pathogenesis of human immunodeficiency virus (HIV) in the lymphoid
compartment has a dramatic effect on disease progression and importan
t implications for therapeutic and vaccine strategies. Here we discuss
current understanding of the pathogenesis of HIV in the lymphoid tiss
ue. Various model systems that allow examination of the effect of retr
oviral infection in primary lymphoid organs are discussed, as well as
current progress made with the use of these systems, with particular e
mphasis on the SCID-hu mouse.