HIV TYPE-1 INFECTION IN LYMPHOID-TISSUE - NATURAL-HISTORY AND MODEL SYSTEMS

The pathogenesis of human immunodeficiency virus (HIV) in the lymphoid compartment has a dramatic effect on disease progression and importan t implications for therapeutic and vaccine strategies. Here we discuss current understanding of the pathogenesis of HIV in the lymphoid tiss ue. Various model systems that allow examination of the effect of retr oviral infection in primary lymphoid organs are discussed, as well as current progress made with the use of these systems, with particular e mphasis on the SCID-hu mouse.