M. Halsas et al., EFFECT OF DIFFERENT COMBINATIONS OF HYDROXYPROPYLMETHYL CELLULOSE ON BIOAVAILABILITY OF IBUPROFEN FROM PRESS-COATED TIME-CONTROLLED TABLETS, STP PHARMA SCIENCES, 8(3), 1998, pp. 155-161
Many diseases have diurnal rhythms which should be taken into consider
ation when developing dosage forms. in the study described here, time-
controlled formulation for chronopharmacotherapy: of diseases, e.g. ar
thritis, was developed. The formulation is a press-coated tablet in wh
ich the coat contains hydroxypropylmethyl cellulose to control drug re
lease. The drug dose can be divided between the cor-e and the cent. Th
e main objective was to investigate how the drug release and pharmacok
inetic profile of ibuprofen could be modified by combinations of diffe
rent viscosity grades of HPMC (Methocel K100 and K4M). It can be concl
uded that with the present kind of time-controlled formulation the poi
nt of the peak plasma level can be adjusted to 6 to 8 h. If the maxima
l effect is desired irt the early morning hours, drug dosing could tak
e place between 8 to 10 PM. In addition, a double peak plasma profile
could be obtained if more continuous plasma levels are desirable.