DEVELOPMENT OF AN EXPERIMENTAL-METHOD FOR MEASURING THE ADHESION OF GELIFIED FORMULATIONS USING TEXTURE ANALYZERS

The purpose of this research was to study the adhesion of gelified buc coadhesive formulations. These formulations are composed of different derivatives belonging to the bioadhesive polymer categories described in the literature (polyanionic, polycationic, non-ionic), as well as t o a special category, the oleic derivatives. These different molecules are dispersed in hydrophilic liquid phases. The consistency and adhes ion of these formulations are then tested using two texture analysers: the TA-XT2 (Rheo) and the LFRA (Stevens). Adhesion is measured, using the TA-XT2 texture analyser, on glass slides coated or not with a sin gle layer of human buccal epithelial cells and artificial saliva. The formulations which prove to be the most effective in these in vitro te sts are then subjected to tests with volunteers and are compared to a trade reference and to another formulation chosen expressly for the po or adhesiveness of its polymer: The results of this in vivo test allow ed us to verify the soundness of our in vitro assessment methods in co mparison with a subjective appreciation of the bioadhesive properties of the formulations.