K. Lewis, AUDIT OF TIMING OF ANTIBIOTIC-PROPHYLAXIS IN HIP AND KNEE ARTHROPLASTY, Journal of the Royal College of Surgeons of Edinburgh, 43(5), 1998, pp. 339-340
Infection following arthroplasty can have devastating consequences. An
tibiotic prophylaxis is routinely given in modern orthopaedic practice
in an attempt to reduce infection rates. The aim is to achieve clinic
ally useful tissue concentrations of antibiotic peri-operatively, and
this is accomplished with antibiotic administration at induction of an
aesthesia and at 6 and 12 h post-operatively. The case notes of 16 con
secutive patients undergoing elective joint replacement surgery were r
eviewed. All received antibiotic prophylaxis, but the time intervals b
etween doses were longer than the current standard in 50% of patients
for the second dose and 81% of patients for the third dose. Our practi
ce has been reviewed to ensure that all patients receive antibiotics a
t the appropriate times.