STRUCTURE ELUCIDATION OF SCH-49088, A NOVEL EVERNINOMICIN ANTIBIOTIC CONTAINING AN UNUSUAL HYDROXYLAMINO-ETHER SUGAR, EVERHYDROXYLAMINOSE

Authors
SAKSENA AK JAO E MURPHY B SCHUMACHER D CHAN TM PUAR MS JENKINS JK MALONEY D CORDERO M PRAMANIK BN BARTNER P DAS PR MCPHAIL AT GIRIJAVALLABHAN VM GANGULY AK
Citation
Ak. Saksena et al., STRUCTURE ELUCIDATION OF SCH-49088, A NOVEL EVERNINOMICIN ANTIBIOTIC CONTAINING AN UNUSUAL HYDROXYLAMINO-ETHER SUGAR, EVERHYDROXYLAMINOSE, Tetrahedron letters, 39(46), 1998, pp. 8441-8444
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
46
Year of publication
1998
Pages
8441 - 8444
Database
ISI
SICI code
0040-4039(1998)39:46<8441:SEOSAN>2.0.ZU;2-0
Abstract
Degradation of Sch 49088 (1) provided a novel, highly functionalized O -substituted hydroxylamine-containing sugar, everhydroxylaminose 11 is olated as a beta-OMe glycoside. Notably the two acid sensitive orthoes ter moieties in the intact antibiotic 1 co-exist in the presence of th ree phenolic groups and a free carboxylic acid group. (C) 1998 Elsevie r Science Ltd. All rights reserved.