TRIPHENYLPHOSPHINE SCANDIUM(III) TRIFLUOROMETHANESULFONATE - A NEW AGENT FOR THE REFORMATSKY REACTION OF ALPHA-BROMO CARBOXYLIC-ACID DERIVATIVES WITH ALDEHYDES/

Authors
KAGOSHIMA H HASHIMOTO Y SAIGO K
Citation
H. Kagoshima et al., TRIPHENYLPHOSPHINE SCANDIUM(III) TRIFLUOROMETHANESULFONATE - A NEW AGENT FOR THE REFORMATSKY REACTION OF ALPHA-BROMO CARBOXYLIC-ACID DERIVATIVES WITH ALDEHYDES/, Tetrahedron letters, 39(46), 1998, pp. 8465-8466
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
46
Year of publication
1998
Pages
8465 - 8466
Database
ISI
SICI code
0040-4039(1998)39:46<8465:TST-AN>2.0.ZU;2-T
Abstract
The Ph3P/Sc(OTf)(3) combination was found to be effective for the Refo rmatsky reaction; when alpha-bromo carboxylic acid derivatives were al lowed to react with aldehydes in the presence of the Ph3P/Sc(OTf)(3) c ombination, the corresponding beta-hydroxy carboxylic acid derivatives were obtained in good yields with excellent diastereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.