STUDIES ON QUINAZOLINES IX - FLUORINATION VERSUS 1,2-MIGRATION IN THEREACTION OF 1,3-BIFUNCTIONALIZED AMINO-2-PROPANOL WITH DAST

Authors
CHERN JW CHANG JY USIFOH CO GUTSAIT A
Citation
Jw. Chern et al., STUDIES ON QUINAZOLINES IX - FLUORINATION VERSUS 1,2-MIGRATION IN THEREACTION OF 1,3-BIFUNCTIONALIZED AMINO-2-PROPANOL WITH DAST, Tetrahedron letters, 39(46), 1998, pp. 8483-8486
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
46
Year of publication
1998
Pages
8483 - 8486
Database
ISI
SICI code
0040-4039(1998)39:46<8483:SOQI-F>2.0.ZU;2-J
Abstract
Treatment of ino-3-[4-(2-methoxyphenyl)piperazin-1-yl]-propanol (7) wi th DAST induced 1,2-migration via a proposed spiro-aziridinium interme diate to give 2-methoxyphenyl)piperazin-1-yl]propyl]-phthalimide (11a) in 13 % yield and (2-methoxyphenyl)-piperazin-1-yl]ethyl]phthalimide (11b) in 73% Yield. (C) 1998 Elsevier Science Ltd. All rights reserved .