Background: Exact determination of the location of the fovea may be di
fficult, especially in patients suffering from macular pathology. The
purpose of this study was to evaluate whether the distance between the
optic nerve head and fovea in healthy eyes may be helpful in such pat
ients. Patients and methods: We measured the distance between the cent
er of the optic nerve head and the fovea in 165 healthy eyes in a hori
zontal and vertical direction. Results were correlated to the refracti
ve status. Results: There was a relatively high deviation between all
eyes for the distance between the optic disc and the fovea (15.5 +/- 1
.2 degrees [12.8 to 21.3 degrees]). There was a significant relationsh
ip between this distance and the refraction (r = 0.353, P<0.001). Intr
aindividual deviation between the right and left eyes showed a markedl
y lower variance (0.67 +/- 0.49 degrees [0.05 to 2.3 degrees]). Conclu
sion: The distance between the optic nerve head and the fovea does not
allow for meaningful determination of the location of the fovea in ey
es in which morphological changes have occurred. However, knowledge of
this distance from the other eye of the same patient is helpful.